Is Simparica Trio Safe for Dogs?

There are numerous regular monthly heartworm preventatives to decide on from, which can make it overpowering for pet mothers and fathers to determine which is the ideal solution for their pet. Simparica Trio is a preferred all-in-one particular oral preventative that guards dogs from heartworm disease, fleas, ticks, roundworms, and hookworms. 

So, is Simparica Trio protected for dogs? This medication may perhaps not be suited for all canine, but in consultation with your veterinarian, you can come to feel assured you’re utilizing a harmless and powerful product for your canine companion. 

Let us dive into what the research demonstrate and what pet mothers and fathers can expect when administering Simparia Trio for canines. 

What Is Simparica Trio?

Simparica Trio for canines is an Fda-authorized preventative medication presented at the time month to month to defend canines versus specific kinds of parasites. It is only available by prescription by your pet’s veterinarian. 

This flavored chewable pill incorporates 3 energetic elements: sarolaner, moxidectin, and pyrantel. Sarolaner is successful against fleas and ticks, even though moxidectin helps prevent heartworm sickness. Pyrantel is a deworming medication that treats and controls two varieties of intestinal parasites, roundworms and hookworms. 

Simparica Vs. Simparica Trio

Typical Simparica is a different oral chewable tablet for puppies. A reward of equally Simparica and Simparica Trio is that they each get rid of deer ticks (aka blacklegged ticks) and are hence Food and drug administration-authorised to protect against bacterial infections that may well trigger Lyme condition in dogs, a serious health issues that can severely influence the joints and kidneys. 

Even so, normal Simparica is only powerful against fleas and ticks and does not provide security towards heartworm disorder or intestinal parasites. If you want to have this supplemental protection for your pet dog, Simparica Trio is a much better solution.

Is Simparica Trio Protected for Pet dogs?

SImparica Trio for dogs

When utilised as recommended, Simparica Trio is risk-free and successful for most canines, such as individuals who are heartworm-positive [1, 2, 3]. Puppies and puppies using this treatment need to be at least 8 months outdated and weigh at the very least 2.8 pounds.

There are several reasons Simparica Trio might be picked out about other offered products and solutions. It was the to start with all-in-a single merchandise to hit the sector that is given as soon as every month to guard versus fleas, ticks, heartworm condition, and sure kinds of intestinal parasites. (A 2nd all-in-one particular solution, NexGard Additionally, was released in July 2023.) Simparia Trio was also shown to be 100 p.c successful at managing heartworm disease and proficiently kills 5 different styles of ticks in contrast to other brand names [3, 4]. 

Before prescribing this treatment, veterinarians will affirm your canine satisfies the excess weight and age necessities to assure protection. Certain health conditions, this sort of as a heritage of seizures, could increase the threat of facet effects, so veterinarians will diligently think about the exclusive well being position and desires of your puppy prior to prescribing Simparica Trio. Simparica Trio has not been analyzed in expecting or nursing pet dogs, so its protection is mysterious in this group. 

Since Simparica Trio contains sarolaner, which is an isoxazoline drug, it must be applied cautiously in canine who are regarded to have experienced seizures in the past or who are presently being handled for seizure conditions. It should really also be applied with warning in canine who have been diagnosed with a neurological issue. Simparica Trio can lead to neurological facet results, this kind of as incoordination, muscle mass tremors, and seizures even in canines without the need of a heritage of these problems, but these scenarios are rare. 

Furthermore, Collies and Australian Shepherds can have a particular gene mutation that makes them far more delicate to ivermectin, a treatment that belongs to the identical drug class as moxidectin in Simparica Trio. Simply because of this, Collies and Australian Shepherds may possibly encounter additional adverse results from Simparica Trio than other breeds. Your veterinarian may perhaps advise making use of a unique regular preventative for these breeds immediately after an evaluation and discussion in the course of their veterinary go to. 

Some dogs may practical experience sensitivities to one particular or additional of the active components in Simparica Trio, which can trigger neurological difficulties or other aspect results, such as vomiting or diarrhea. If adverse effects occur when your canine is taking this treatment, normally achieve out to a veterinarian instantly. Your veterinarian may well propose you swap to a further treatment that is much better tolerated. 

Simparica Trio for Puppies: Precautions to Contemplate

When administering Simparica Trio to your pet, it is significant to observe for aspect effects. Despite the fact that this medicine is typically effectively-tolerated in most puppies, frequent side effects from Simparica Trio that pet mothers and fathers may possibly see contain:

  • Vomiting
  • Diarrhea
  • Lowered urge for food
  • Lethargy

These facet outcomes normally make improvements to the moment the treatment is discontinued. If you discover 1 of these aspect results, it’s essential to call your veterinarian for direction. Your pet dog may be switched to another monthly preventative that is extra suited for them. 

Pet dogs require to be tested for present heartworm infections prior to beginning a preventative. Considering that Simparica Trio kills heartworm larvae, not adult heartworms, puppies identified with heartworm disorder would will need to be handled with an adulticide to get rid of adult heartworms. In other text, if a dog is identified with heartworm disorder, they would will need to be on both of those an adulticide and a every month preventative.

There are no adverse reactions now identified for dogs getting Simparica Trio concurrently with many other medications, including vaccines, NSAIDs, steroids, antibiotics, and deworming drugs. The treatment can also be employed safely and securely in canines going through anesthetic techniques, these types of as spaying, neutering, or dental procedures. Even so, it is always vital to have a discussion with your veterinarian about any medicines or health supplements your pet is taking prior to administering Simparica Trio. 

Pet mothers and fathers ought to be informed that it is feasible for puppies to overdose on Simparica Trio. Accidental overdose increases the threat for significant side effects, specifically in breeds with sensitivities to the active substances in this medication. To avert accidental overdose, pet parents must only give this medicine as approved by their veterinarian and assure that the medicine is stored securely out of arrive at of animals at all situations. 


  1. Mathur, S., Malpas, P.B., Mahabir, S. et al. Basic safety of Simparica Trio® (sarolaner, pyrantel, moxidectin) in heartworm-contaminated canine. Parasites Vectors 16, 119 (2023). 
  2. Kryda, K., Mahabir, S.P., Inskeep, T. et al. Safety and efficacy of a novel oral chewable combination tablet that contains sarolaner, moxidectin and pyrantel (Simparica Trio™) against all-natural flea infestations in consumer-owned dogs in the United states of america. Parasites Vectors 13, 98 (2020).
  3. Kryda, Kristina et al. “Efficacy of a novel orally administered combination products containing sarolaner, moxidectin and pyrantel (Simparica Trio™) against induced infestations of 5 frequent tick species infesting puppies in the United states of america.” Parasites & vectors vol. 13,1 77. 1 Mar. 2020, doi:10.1186/s13071-020-3945-2
  4. Kryda, K., 6, R.H., Walsh, K.F. et al. Laboratory and area scientific studies to look into the efficacy of a novel, orally administered mix product or service made up of moxidectin, sarolaner and pyrantel for the avoidance of heartworm disorder (Dirofilaria immitis) in canines. Parasites Vectors 12, 445 (2019).

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