Cisapride for Cats

Dog medication in bottle

Cats who endure from a wide range of gastrointestinal (GI) disorders might advantage from normal use of cisapride, a medicine that can enable your cat deal with GI conditions these as persistent constipation or megacolon. If other procedure selections have failed to thoroughly improve your cat’s intestine wellness, talk with your veterinarian about the use of cisapride.

What follows is every little thing you will need to know about cisapride, like what it’s made use of for in cats, likely facet outcomes, and how to give this medicine.

What Is Cisapride?

Cisapride is a gastrointestinal promotility (or prokinetic) drug, which signifies it will help shift ingested meals (and later feces) in the suitable direction—downward by the GI tract.

Cisapride is a generic treatment that can only be received through a prescription from your veterinarian. It was initially readily available for human utilization but was withdrawn from the typical current market in 2000 owing to most likely lethal cardiac issues. In folks, cisapride can extend the QT interval in the coronary heart, which means electrical action of the heart results in being irregular and can progress to irregular heart rhythms (ventricular arrhythmias) that can cause fainting (syncope) and sudden dying.

Fortunately, these kinds of cardiac challenges from cisapride use surface to be extremely uncommon in puppies and cats and have not been documented by the veterinary group. Having said that, due to the fact cisapride no extended has Food and drug administration approval, it is not commercially out there in North America. It need to be procured exclusively from your frequent vet or compounding pharmacy as a generic drug with “off-label” use in canine and cats. 

Is Cisapride Harmless for Cats?

Cisapride is viewed as an general risk-free treatment in the bulk of cats when made use of at a appropriate dosage as suggested by a veterinarian.

What Does Cisapride for Cats Search Like?

Considering the fact that cisapride is obtainable only in compounded kind, it could be formulated in a wide range of means. Cisapride is largely offered in oral kind as a flavored or unflavored liquid, capsule, or pill. Tablets may well be frequent, chewable, mini-tabs, or melt tabs. Some compounding pharmacies may also make cisapride in a transdermal gel that is applied topically. Nevertheless, oral forms are inclined to be a lot more successful, as they are extra easily absorbed by the overall body.

How Does Cisapride Operate?

Commonly, sleek muscle tissues instantly contract to drive food downward through the digestive tract this is referred to as peristalsis. Having said that, some cats have issues that gradual the movement of gut activity, leading to impaired GI operate. Cisapride functions instantly on the tummy, modest intestine, and significant intestine (colon) to pace the transit of ingested food stuff via the GI tract and facilitates defecation. It also increases peristalsis in the reduce esophagus to help prevent reflux.

In small, cisapride retains the GI tract moving in the right direction, aiding cats stay clear of difficulties like serious constipation and fecal impaction. 

Cisapride is a relative of a medication identified as metoclopramide. However, cisapride is regarded as remarkable because it is effective on the colon, whilst metoclopramide has no colonic influence. Also, metoclopramide can cross above into the brain and induce hyperexcitability. Cisapride does not cross the blood-mind barrier.

What Is Cisapride Made use of for in Cats?

As discussed before, Cisapride’s key use is to preserve the intestine moving at a usual pace in the suitable route by improving smooth muscle mass perform. Thus, it is useful for a variety of healthcare disorders in cats these kinds of as:

  • Esophagitis (inflammation of the esophagus)
  • Main gastric stasis conditions (e.g., delayed gastric emptying, intestinal ileus)
  • Serious constipation (issue passing stool) and bloating
  • Megacolon
  • Certain urinary retention problems
  • Once in a while for hairball problems

Examine on for additional explanation on how cisapride can assistance cats with these difficulties:


Cisapride minimizes esophageal reflux and risk of esophageal stricture development.

Main gastric stasis diseases

Examples of primary gastric stasis ailments in cats consist of delayed gastric emptying and intestinal ileus. 

Delayed gastric emptying: This problem happens when the muscle groups and nerves of the tummy do not result in usual contractions to transfer ingested food items out of the tummy and into the small intestine for further more processing. Delayed gastric emptying can lead to serious vomiting.

Intestinal ileus: This refers to a lack of motility largely of the compact intestine.

Even though cisapride can enable decrease vomiting from these issues by protecting against meals from backing up in the tummy, pet moms and dads ought to be aware that cisapride does not have further anti-nausea qualities. It really should not be employed as an anti-emetic substitute for other occasions that induce nausea in cats.

Persistent constipation and bloating

If eating plan adjustments, stool softeners or laxatives, and bulking agents this kind of as fiber health supplements have failed to enhance your cat’s constipation troubles, your vet may possibly increase cisapride as a mode to additional boost the relieve of your cat’s bowel actions.


This dysfunction final results from impairment of the muscle tissues and nerves that management bowel function. Megacolon is secondary to problems from stretching of the colon thanks to continual constipation or fecal obstruction (i.e. obstipation). Megacolon stops the colon from emptying stool, which can lead to issues defecating and bowel obstruction.

Particular urinary retention diseases

Cisapride can assistance strengthen bladder muscle mass contraction to facilitate urine voiding.


Cisapride is also once in a while utilised for hairball issues in cats.

How to Give Cisapride to Cats

As mentioned, Cisparide is obtainable in several formulas, these types of as tender chews, capsules, tablets, and liquids. Your cat may possibly have a exceptional desire as to which treatment formulation they will most effortlessly tolerate. Some cats are effortless to give tablets or capsules though other individuals might much more readily settle for a syringe of liquid treatment alternatively. Some cats may possibly favor a flavored medication, such as tuna. Question your compounding pharmacy what varieties are readily available.

Soft chews (compounded)
Cisapride mini melts (compounded)

Cisapride is ordinarily administered each and every 8-12 several hours, based on your vet’s guidelines. Nevertheless cisapride can be presented with or with no foodstuff, it is very best to give it 15-30 minutes prior to a food, since absorption improves with foodstuff. On top of that, foods reduces the likelihood of GI upset as a prospective side result from this treatment.

Cats will practical experience outcomes inside of a handful of several hours adhering to dosing, and individuals effects will stop within just 24 hours of discontinuation of this drug.

Cisapride for Cats Side Outcomes

The good thing is, cisapride is normally very well tolerated with minimal side consequences in cats, including those people with kidney sickness. Even so, some kitties might working experience gentle GI indicators these types of as:

  • Vomiting
  • Diarrhea
  • Stomach pain from cramping

Cisapride really should be prevented if enhanced gastrointestinal motility can lead to harm of the GI tract owing to preexisting disorders, which incorporate:

  • Intestinal or bowel obstruction: Making use of cisapride amid a GI blockage can direct to perforation, which can be deadly. Your vet will execute a physical exam and most likely belly radiographs (X-rays) to ensure no blockage is existing when cisapride is initially recommended.
  • An present GI perforation
  • GI hemorrhage (brilliant crimson or dim stool)
  • Severe hepatic insufficiency (liver sickness): Your vet may perhaps advocate to lower the dose of cisapride by half or stay away from use entirely in cats with liver disorders.

Furthermore, cisapride ought to be applied with warning in expecting or nursing cats. Cisapride has the prospective to induce decline of early being pregnant. This drug is also excreted in milk and could perhaps lead to difficulties in kittens. Cisapride must only be employed in these eventualities if its profit to the female cat outweighs any opportunity danger to her kittens.

In addition, perilous cardiac consequences of cisapride have been established in human beings. Although not noticed in cats, cats using cisapride ought to however be monitored for any cardiac abnormalities as a precaution.

Indicators of Much too Significantly Cisapride in Cats

Toxicity in cats is exceptional and tends to only take place at particularly significant doses of cisapride. Worrisome signals incorporate:

  • Diarrhea
  • Lethargy
  • Uncoordinated, “drunken” movement of the limbs (ataxia)
  • Drooling (hypersalivation)
  • Muscle mass tremors (fasciculations)
  • Agitation and abnormal actions
  • Significant body temperature (hyperthermia)
  • Issue respiratory
  • Seizures

If you observe the previously mentioned symptoms in your cat or suspect they could have been exposed to an overdose of cisapride, phone your vet without delay or the ASPCA Animal Poison Manage Centre at 888-426-4435.

If poisoning has occurred, your vet may perhaps propose to induce vomiting and administer activated charcoal as effectively as present supportive treatment to control indicators.

Reactions with Other Drugs and Medications

Due to the fact of cisapride’s effect at dashing up the transit time by way of the intestine, it can increase the absorption of other oral drugs your cat could be using. Always go above your cat’s total list of remedies and dietary supplements with your veterinarian prior to starting up cisapride.

Cisapride can interact negatively with selected medications, this sort of as all those detailed below. Therefore, concurrent use should be avoided and mentioned with your vet:

  • Anticholinergic agents, this sort of as atropine
  • Benzodiazepines, these kinds of as injectable diazepam or midazolam: can worsen sedation outcomes
  • Specified antihistamines/antacids, such as famotidine, cimetidine, and ranitidine
  • Anticoagulants
  • Cyclosporine
  • Furosemide
  • Ondansetron
  • Opioids
  • Some fluoroquinolone antibiotics
  • Silymarin (milk thistle)
  • Antifungals, such as itraconazole or ketoconazole
  • Chloramphenicol
  • Some macrolide antibiotics, apart from azithromycin
  • Some cardiac drugs, these as amiodarone or sotalol
  • Tricyclic antidepressants, these types of as amitriptyline

Cisapride Dose for Cats

Only your vet ought to immediate you as to the specific dose and frequency of cisapride your cat need to receive. Each person cat is diverse centered on a wide variety of factors, this sort of as the cat’s excess weight and correct GI dysfunction and its severity.

Your cat’s cisapride dose could will need to be little by little elevated or or else modified by your vet to optimize its outcome. Even so, pet parents need to hardly ever change their cat’s dose on their personal without a vet’s direction.

What If My Cat Misses a Dose of Cisapride?

If your cat unintentionally misses a dose of cisapride, merely wait and give it when the up coming dose is due and resume the recommended protocol going ahead. Do not double up or give more doses not prescribed by your vet.

Price of Cisapride for Cats

The cost of cisapride differs commonly depending on your cat’s dosage (milligrams needed as properly as frequency), the formulation you select from your compounding pharmacy, as effectively as your geographic area. On typical, you can count on to pay back $45-$80 for a 30-day supply of your cat’s cisapride based mostly on the aforementioned variables.

Cisapride Storage Guidelines

Cisapride should really be shielded from mild and dampness in a limited, sealed container. Until specified otherwise on your compounded product or service, this medicine really should be stored at area temperature.

The put up Cisapride for Cats appeared initially on Terrific Pet Treatment.